Do Antibodies Stimulate Myelin Repair in Multiple Sclerosis?
نویسندگان
چکیده
منابع مشابه
Do myelin-directed antibodies predict multiple sclerosis?
Multiple sclerosis is characterized by recurrent neurologic events (clinical relapses) that are attributable to multifocal lesions within the central nervous system. Lesions referred to as “active plaques” are characterized by the presence of inflammation and active myelin degradation and phagocytosis. These lesions have been subtyped according to the relative presence of immunoglobulin (i.e., ...
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OBJECTIVE To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals. DESIGN Prospective case-control series. SETTING Academic referral center. PATIENTS Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant...
متن کاملAnti-myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
Can serum antibodies to myelin oligodendrocyte glycoprotein (MOG) be used as a marker of multiple sclerosis (MS) or to predict the course of MS? Recent articles present conflicting data in response to these questions. Berger et al.1 tested for presence of serum antibodies to MOG in patients experiencing a first clinically isolated syndrome suggestive of MS. Those who progressed almost invariabl...
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Anti-myelin basic protein (MBP) antibodies in pediatric-onset MS and controls were characterized. Serum samples were obtained from 94 children with MS and 106 controls. Paired CSF and serum were obtained from 25 children with MS at time of their initial episode of acute demyelinating syndrome (ADS). Complementary assays were applied across samples to evaluate the presence, and the physical bind...
متن کاملTherapeutic Applications of Monoclonal Antibodies in Multiple Sclerosis
Despite the various therapies available, the use of monoclonal antibodies is a highly specific approach that has only recently been of interest to researchers. The properties of antibodies have led to their use in the treatment of various diseases, including cancer, Alzheimer's disease, diabetes and multiple sclerosis (MS). MS, a chronic inflammatory disease, occurs commonly in young adults. Th...
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ژورنال
عنوان ژورنال: The Neuroscientist
سال: 1999
ISSN: 1073-8584,1089-4098
DOI: 10.1177/107385849900500104